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CD44

概要

Name:CD44 antigen
Target Synonym:Hermes Antigen,Hyaluronate Receptor,Cell Surface Glycoprotein CD44,MC56,PGP-1,CD44,CDW44,GP90 Lymphocyte Homing/Adhesion Receptor,MIC4,LHR,Hematopoietic Cell E- And L-Selectin Ligand,CD44 Antigen (Homing Function And Indian Blood Group System),MDU3,Extracellular Matrix Receptor III,Heparan Sulfate Proteoglycan,HUTCH-I,ECMR-III,Epican,Chondroitin Sulfate Proteoglycan 8,Soluble CD44,MDU2,Pgp1,CSPG8,HCELL,Phagocytic Glycoprotein 1,Indian Blood Group Antigen,IN,Phagocytic Glycoprotein I,CD44 Molecul
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:10
Lastest Research Phase:Phase 3 Clinical

製品リスト製品比較と製品注文

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製造番号 種類 製品説明 構造 純度 特徴
HGS-S246 Rabbit Recombinant Monoclonal Anti-CD44 Antibody, Rabbit (5G3)
PG1-H5255 Human Human CD44 Protein, Fc Tag (HPLC-verified)
PG1-H5255-structure
PG1-H5255-sds
PG1-H5255-hplc
CD4-H5226 Human Human CD44 Protein, His Tag
CD4-H5226-structure
CD4-H5226-sds
ACRO Quality

生物活性データの一部

CD4-H5226-ELISA
 CD44 ELISA

Immobilized Human CD44, His Tag (Cat. No. CD4-H5226) at 5 μg/mL (100 μL/well) can bind Hyaluronan biotin sodium salt with a linear range of 39-156 ng/mL (Routinely tested).

PG1-H5255-ELISA
 CD44 ELISA

Immobilized Hyaluronic Acid at 100 μg/mL (100 μL/well) can bind Human CD44 Protein, Fc Tag (Cat. No. PG1-H5255) with a linear range of 0.156-2.5 μg/mL (Routinely tested).

Synonym Name

CD44,CDW44,CSPG8,ECMR-III,HCELL,HUTCH-I,IN,LHR,MC56,MDU2,MDU3,MIC4,Pgp1,Epican

Background

CD44 antigen is a cell-surface glycoprotein involved in cell¨Ccell interactions, cell adhesion and migration. CD44 is expressed in a large number of mammalian cell types. CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
Clodronic acid/Hyaluronic acid Phase 1 Clinical Abiogen Pharma Spa Osteoarthritis Details
AMC-303 AMC-303; HP-558 Phase 1 Clinical Amcure Gmbh Solid tumours; Esophageal Squamous Cell Carcinoma Details
Hyaluronic acid/Fluorouracil HA-5FU; HA-5-fluorouracil; Hyaluronic acid-5-fluorouracil complex; Hyaluronan acid-5-fluorouracil complex Phase 2 Clinical Monash University, Alchemia Ltd Colorectal Neoplasms Details
BGC-0228 BGC-0228 Phase 1 Clinical Brightgene Bio-Medical Technology Co Ltd Solid tumours Details
CD44v6-specific CAR gene-engineered T cell therapy (Shenzhen Geno-Immune Medical Institute) 4SCAR-CD44v6 Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Neoplasms Details
CA-102N CA-102N Phase 2 Clinical Biobud Solid tumours; Colorectal Neoplasms Details
Paclitaxel/Hyaluronic acid Phase 3 Clinical Fidia Pharma Carcinoma, Papillary; Urinary Bladder Neoplasms Details
Multiple 4SCAR-T Cell Therapy (Shenzhen Geno-Immune Medical Institute) Phase 2 Clinical Shenzhen Geno-Immune Medical Institute Breast Neoplasms Details
AMT-116(Multitude Therapeutics) AMT-116; AMT-116-ADC Phase 1 Clinical Head and Neck Neoplasms; Solid tumours; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Hyaluronic acid inhalation (Actelion Pharmaceuticals) ETX-100; CTX-100 Actelion Pharmaceuticals Ltd Details
Hydrogen peroxide/Hyaluronic acid BMG-0703 Phase 3 Clinical University Of Milan Periodontal Pocket; Bruxism; Gingival Hemorrhage; Gingivitis; Surgical Wound; Periodontitis Details

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