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HLA-A*1101 & B2M & KRASG12S (VVVGASGVGK)

HLA-A*1101 & B2M & KRASG12S (VVVGASGVGK) 製品リスト

属性
Protein (1)
製品ライブラリ
オンライン (1)
種
Human (1)
タグ
His Tag & Avi Tag (1)
マーカー
Biotin-labeled (1)

製品番号	種	発現システム	製品説明	タンパク質の構造	純度	特性
HLS-H82E8	Human	HEK293	Biotinylated Human HLA-A*11:01&B2M&KRASG12S (VVVGASGVGK) Complex Protein (Monomer, MALS verified)

総数量1

HLA-A*1101 & B2M & KRASG12S (VVVGASGVGK)バックグランド

The peptide VVVGASGVGK, derived from the KRAS G12S mutation and presented by the HLA-A*11:01/β2-microglobulin (β2m) complex, is a pivotal antigenic target in antitumor immunity. This complex plays a crucial role by activating specific cytotoxic T lymphocytes (CTLs), enabling the immune system to recognize and eliminate tumor cells harboring the KRAS G12S mutation.

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
Paltusotine	CRN-00808	Phase 3 Clinical	Crinetics Pharmaceuticals Inc	Acromegaly; Malignant Carcinoid Syndrome; Neuroendocrine Tumors	詳細
Lutetium-177 labelled edotreotide	ITM-11	Phase 3 Clinical	Universitaetsspitals Basel, Itm Solucin Gmbh	Solid tumours; Pancreatic neuroendocrine tumors (pNET); Neuroendocrine Tumors; Central Nervous System Neoplasms; Thymus Neoplasms; Lung Neoplasms; Lymphoma; Carcinoma, Neuroendocrine	詳細
RYZ-101	RYZ-101	Phase 3 Clinical		Carcinoid Tumor; Stomach Neoplasms; Pancreatic neuroendocrine tumors (pNET); Small Cell Lung Carcinoma; Neuroendocrine Tumors; Carcinoma, Neuroendocrine; Gastrointestinal Neoplasms	詳細
Gallium-68 satoreotide	68Ga-OPS-202; 68Ga IPN-1070; 68Ga-DOTA-JR11	Phase 2 Clinical	Ipsen Inc	Stomach Neoplasms; Pancreatic neuroendocrine tumors (pNET); Small Cell Lung Carcinoma; Breast Neoplasms; Gastrointestinal Neoplasms	詳細
Nendratareotide uzatansine	BTP-277; PEN-221	Phase 2 Clinical	Tarveda Therapeutics Inc	Small Cell Lung Carcinoma; Neuroendocrine Tumors; Carcinoma, Neuroendocrine	詳細
Yttrium 90-labelled edotreotide	SMT-487-[90Y]; DOTATOC-[90Y]	Phase 2 Clinical	The University Of Iowa, Novartis Pharma Ag	Central Nervous System Neoplasms; Meningioma; Melanoma; Lymphoma; Lung Neoplasms; Sarcoma; Neuroblastoma; Breast Neoplasms; Brain Neoplasms; Solid tumours; Neuroendocrine Tumors; Small Cell Lung Carcinoma; Adenoma, Islet Cell; Neoplasms; Pheochromocytoma; Carcinoid Tumor; Medulloblastoma	詳細
Dopastatin	TBR-760; BIM-23A760	Phase 2 Clinical	Ipsen	Acromegaly; Malignant Carcinoid Syndrome; Adenoma; Pituitary Neoplasms	詳細
ZT-01	ZT 01; ZT-01	Phase 2 Clinical	Tulane University, York University, University Of Toronto, Toronto	Diabetes Mellitus, Type 1; Hypoglycemia	詳細
Re-188 P 2045	P2045; BAY-865284; Rhenium-188 P2045; Re-188 P 2045; Rh-188 P2045; Rhenium-188-P-2045	Phase 2 Clinical	Bayer AG	Neoplasm Recurrence, Local; Small Cell Lung Carcinoma; Neuroendocrine Tumors; Lung Neoplasms; Carcinoma, Small Cell; Carcinoma, Non-Small-Cell Lung	詳細
[203-Pb] VMT-NET	[203-Pb] VMT-NET	Phase 2 Clinical	Perspective Therapeutics Inc	Head and Neck Neoplasms; Pheochromocytoma; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Neuroendocrine Tumors; Paraganglioma	詳細
64Cu-SarTate		Phase 2 Clinical	University Of Melbourne	Neuroendocrine Tumors; Neuroblastoma; Meningioma	詳細
Lutetium-177 DOTA satoreotide	[177Lu]LuSSO110; 177Lu-IPN-1072; OPS-201; 177Lu-IPN01072; 177LU-OPS 201; 177Lu-DOTA- JR11; 177Lu-satoreotide	Phase 1 Clinical	Ipsen, OctreoPharm Sciences GmbH	Small Cell Lung Carcinoma; Breast Neoplasms; Meningioma	詳細
CRN-01941	CRN-01941	Phase 1 Clinical	Crinetics Pharmaceuticals Inc		詳細
68Ga-NOTA-3PTATE-RGD	68Ga-NOTA-3PTATE-RGD; 68Ga-NOTA-3P-TATE-RGD	Phase 1 Clinical	Peking Union Medical College Hospital	Small Cell Lung Carcinoma; Neuroendocrine Tumors; Lung Neoplasms	詳細
[99mTc]Tc-TECANT1		Phase 1 Clinical	Ljubljana University Medical Centre, Medical University Of Innsbruck, Narodowe Centrum Badan Jadrowych, Jagiellonian University Sylff Fellows Association	Neuroendocrine Tumors	詳細
161Tb-DOTA-LM3	161Tb-DOTA-LM3	Phase 1 Clinical	University Hospital Basel	Pancreatic neuroendocrine tumors (pNET); Neuroendocrine Tumors	詳細
44Sc-edotreotide	44Sc-edotreotide; 44Sc-DOTA-[3-Tyr]-octreotide; Sc44-DOTATOC	Clinical	Zentralklinik Bad Berka	Diagnostic agents	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Pasireotide Pamoate		Approved	Novartis Pharma Ag	Signifor lar	United States	Acromegaly	Recordati Rare Diseases Inc	2014-12-15	Gigantism; Acromegaly; Cushing Syndrome; Carcinoid Tumor; Pituitary ACTH Hypersecretion; Neuroendocrine Tumors; Meningioma	詳細
Lutetium (177Lu) oxodotreotide	Lu-DOTATATE; Lutetium (177Lu) DOTA-TATE; 177Lu-DOTATATE; [Lu-177]-DOTATATE; AAA-601; F-1515; XTR-008; [177Lu]Lu-DOTA-TATE	Approved		Lutathera	EU	Neuroendocrine Tumors	Advanced Accelerator Applications Sa	2017-09-26	Breast Neoplasms; Carcinoid Heart Disease; Meningioma; Paraganglioma; Metastatic breast cancer; Lung Neoplasms; Carcinoma, Neuroendocrine; Pituitary Neoplasms; Medullary thyroid cancer (MTC); Neuroblastoma; Prostatic Neoplasms; Liver Neoplasms; Neuroendocrine Tumors; Malignant Carcinoid Syndrome; Pancreatic neuroendocrine tumors (pNET); Pancreatic Neoplasms; Adenoma, Islet Cell; Bronchial Neoplasms; Carcinoid Tumor; Pheochromocytoma; Leiomyosarcoma	詳細
Vapreotide Acetate	RC-160; BMY-41606	Approved	Debiopharm Group	Sanvar, Docrised, Sanvar IR, Sanvar SR					Acromegaly; Hypertension, Portal; Pancreatic Neoplasms; Hemorrhage; Neuroendocrine Tumors; Diarrhea; Intraoperative Complications; Postoperative Complications; Esophageal and Gastric Varices; Crohn Disease	詳細
Pasireotide Diaspartate	SOM-230; SOM-230C; SOM-320	Approved	Novartis Pharma Ag	Signifor, 丝尼芬	EU	Cushing Syndrome	Recordati Rare Diseases Inc	2012-04-24	Pituitary Neoplasms; Uveal melanoma; Prostatic Neoplasms, Castration-Resistant; Cysts; Pituitary ACTH Hypersecretion; Medullary thyroid cancer (MTC); Prostatic Neoplasms; Hyperinsulinism; Nelson Syndrome; Multiple Myeloma; Thyroid Neoplasms; Thymoma; Meningioma; Prolactinoma; Gastrointestinal Neoplasms; Carcinoma, Hepatocellular; Cluster Headache; Acromegaly; Neuroendocrine Tumors; Liver Cirrhosis; Kidney Diseases; Small Cell Lung Carcinoma; Pancreatic Neoplasms; Neoplasms; Adenoma, Islet Cell; Hypoglycemia; Dumping Syndrome; Insulinoma; Carcinoid Tumor; Cushing Syndrome; Alcohol-Induced Disorders; Congenital Hyperinsulinism; ACTH Syndrome, Ectopic	詳細
Ga-68 Edotreotide	SMT-487; [68Ga]DOTATOC; 90Y-DOTATOC	Approved		SomaKit TOC, Gallium Dotatoc Ga 68, TOCscan	EU	Diagnostic agents; Neuroendocrine Tumors; Pancreatic neuroendocrine tumors (pNET)	Advanced Accelerator Applications Sa	2016-12-08	Medulloblastoma; Multiple Endocrine Neoplasia Type 1; Carcinoid Tumor; Pancreatic neuroendocrine tumors (pNET); Neuroendocrine Tumors; Neuroblastoma; Pituitary Neoplasms; Diagnostic agents; von Hippel-Lindau Disease; Somatostatinoma; Meningioma; Paraganglioma	詳細
Gallium (68Ga) oxodotreotide	68Ga-DOTA-TATE; 68-Ga-DOTA-TATE	Approved		Netspot	United States	Neuroendocrine Tumors	Aaa Usa Inc	2016-06-01	Pheochromocytoma; Carcinoid Tumor; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Neuroendocrine Tumors; Prostatic Neoplasms; Thyroid Neoplasms; Carcinoma, Neuroendocrine; von Hippel-Lindau Disease; Paraganglioma; Carcinoma, Hepatocellular	詳細