Cynomolgus Cadherin-11 Protein, His Tag (MALS verified)

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Cat. No. / Size
Price
Qty
CA1-C52H3-100ug
$360.00
CA1-C52H3-1mg
$2615.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    Cadherin-11

  • Source

    Cynomolgus Cadherin-11 Protein, His Tag (CA1-C52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 54 - Thr 617 (Accession # A0A2K5TN17).

    Predicted N-terminus: Gly 54

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  • Molecular Characterization

    Cadherin-11 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 63.8 kDa. The protein migrates as 70-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Cadherin-11 SDS-PAGE

    Cynomolgus Cadherin-11 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Cadherin-11 SEC-MALS

    The purity of Cynomolgus Cadherin-11 Protein, His Tag (Cat. No. CA1-C52H3) is more than 90% and the molecular weight of this protein is around 60-90 kDa verified by SEC-MALS.

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Background

Cadherin-11 is a type II cadherin which mediates cell-to-cell homophilic interactions. Cadherin-11 is mainly expressed on mesenchymal cells and is essential for tissue migration and organization during embryogenesis, while its expression on epithelial cancer cells is implicated in tumor progression and metastasis suggesting a potential role in the epithelial-to-mesenchymal transition phenomenon. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. In addition, cadherin-11 has been shown to increase the invasive capacity of Fibroblast-like Synoviocytes (FLS) and consequently be involved in the formation of the rheumatoid pannus.

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