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Human Flt-3 Ligand Protein, His Tag

COADS MS
DS

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製品番号/仕様
価格
数量
FLL-H55H7-100ug
$395.00
FLL-H55H7-1mg (500ug X 2)
$2875.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0
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製品詳細

  • Synonyms

    FLT3LG, FL, FLT3L, Flt3 ligand

  • Source

    Human Flt-3 Ligand, His Tag (FLL-H55H7) is expressed from Baculovirus-Insect cells. It contains AA Thr 27 - Pro 185 (Accession # P49771-1).

    Predicted N-terminus: Thr 27

    Request for sequence

  • Molecular Characterization

    Flt-3 Ligand Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 19.9 kDa. The protein migrates as 22-28 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    Flt-3 Ligand SDS-PAGE

    Human Flt-3 Ligand, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • Bioactivity-ELISA

    Flt-3 Ligand ELISA

    Immobilized Human Flt-3, Fc Tag (Cat. No. FL3-H5258) at 5 μg/mL (100 μL/well) can bind Human Flt-3 Ligand, His Tag (Cat. No. FLL-H55H7) with a linear range of 0.1-1 ng/mL (QC tested).

    Protocol

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バックグランド

FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs.

最新の進展

 
医薬品開発の進捗
  • 英語名：

    Fms-related tyrosine kinase 3 ligand

  • カテゴリ：

  • 市販の医薬品数：

    0 詳細

  • 治験医薬品数：

    2 詳細

  • 最新の開発ステージ：

    Phase 2 Clinical

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