Human IFN-gamma / IFNG Protein, Research GradeResearch use only

  • This product is designed for academic and scientific research institutions.
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製品番号/仕様
価格
数量
IFG-H5213-20ug
$59.00
IFG-H5213-100ug
$149.00
IFG-H5213-1mg (200ug X 5)
$899.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Features and Advantages

    1. Native Conformation: Native sequences, tag-free and natural function.
    2. Reliable Activity: Biological activity calibrated against WHO/NIBSC standards.
    3. Stringent Quality Control: Protein content, purity, and cell-based bioactivity testing for each batch.
    4. Lowest Endotoxin level (<0.01 EU/ug).
    5. Safety Assurance: Sterile filtration through 0.2 μm membrane.
    6. AOF: Animal origin-free raw materials throughout the production process.
  • Synonyms

    Interferon-gamma , Interferon-γ

  • Source

    Human IFN-gamma Protein, Research Grade (IFG-H5213) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Gln 166 (Accession # P01579).

    Predicted N-terminus: Gln 24

    Request for sequence
  • Molecular Characterization

    IFN-gamma Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries no "tag".

    The protein has a calculated MW of 16.8 kDa. The protein migrates as 15 kDa, 19 kDa and 24 kDa±3 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process
  • Quality Description

    ACRO's Research-grade products are suitable for a wide range of cell culture applications, particularly for research use in academic institutions. These products are sterilized by filtration, followed by lyophilization where applicable. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. Biological activity is calibrated against WHO/NIBSC standards when available.
    ACRO's Premium-grade (Pre-GMP) products are characterized by their high quality and enhanced safety profiles, making them ideal for early-stage discovery and manufacturing processes in cell therapy companies. A key advantage is their seamless transition to corresponding GMP-grade versions. Biological activity is calibrated against WHO/NIBSC standards when available. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. In addition, rigorous testing is conducted to ensure the absence of mycoplasma, HCD, and HCP, thereby guaranteeing product safety.

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データ表示

  • SDS-PAGE

    IFN-gamma SDS-PAGE

    Human IFN-gamma Protein, Research Grade on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    IFN-gamma SEC-MALS

    The purity of Human IFN-gamma Protein, Research Grade (Cat. No. IFG-H5213) is more than 90% and the molecular weight of this protein is around 34-44 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     IFN-gamma ELISA

    Immobilized Human IFN-gamma Protein, Research Grade (Cat. No. IFG-H5213) at 5 μg/mL (100 μL/well) can bind Human IFN-gamma R1, Fc Tag (Cat. No. IF1-H5254) with a linear range of 0.2-6 ng/mL (QC tested).

    Protocol
  • Bioactivity-CELL BASE

     IFN-gamma CELL

    Human IFN-gamma IFNG Protein, Research Grade (IFG-H5213) inhibits the proliferation of HT-29 cells. The specific activity of Human IFN-gamma IFNG Protein, Research Grade is > 2.00 x 10^7 IU/mg, which is calibrated against human interferon gamma Standard (NIBSC code: 87/586) (QC tested).

    Protocol

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バックグランド

Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Interferon gamma

  • カテゴリ:

  • 市販の医薬品数:

    4 詳細

  • 治験医薬品数:

    14 詳細

  • 最新の開発ステージ:

    Approved

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