Mouse MMP-8 Protein, His Tag (Pro-form, MALS verified)

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MM8-M52H7-50ug
$360.00
In Stock - Delivery in 1-2 business days
MM8-M52H7-1mg
$2,225.00
In Stock - Delivery in 2-3 weeks
MM8-M52H7
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Synonyms

CLG1 Protein, HNC Protein, MMP-8 Protein, PMNL-CL Protein,

Source

Mouse MMP-8 Protein, His Tag (MM8-M52H7) is expressed from human 293 cells (HEK293). It contains AA Phe 21 - Gly 262 (Accession # O70138-1). It needs to be activated by agents such as APMA in vitro to have hydrolytic activity.

Predicted N-terminus: Phe 21

Molecular Characterization

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 28.9 kDa. The protein migrates as 35-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

Formulation

Supplied as 0.2 μm filtered solution in 25 mM MES, 150 mM NaCl, Glycerol, pH5.5 with trehalose as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.

バックグランド

Matrix metalloproteinase-8(MMP-8)also known as neutrophil collagenase and CLG1,is a member of matrix metalloproteinases (MMPs) family,which degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes as well as pathological processes. MMP-8 may affect the metastatic behavior of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 in the tumor may have a protective effect against lymph node metastasis.