Biotinylated Cynomolgus Mucin-1 / MUC-1 Protein, His,Avitag™ (MALS verified)

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製品番号/仕様
価格
数量
MU1-C82E3-25ug
$380.00
MU1-C82E3-200ug
$1645.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    Mucin 1, MUC1, CD227, EMA, H23AG, KL-6, MAM6, MUC-1, SEC, MUC-1, X, MUC1, ZD, PEM, PEMT, PUM, CA15-3, Episialin

  • Source

    Biotinylated Cynomolgus Mucin-1 Protein, His,Avitag (MU1-C82E3) is expressed from human 293 cells (HEK293). It contains AA Ser 128 - Gly 376 (Accession # XP_005541632.1).

    Predicted N-terminus: Ser 128

    Request for sequence
  • Molecular Characterization

    Mucin-1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 29.9 kDa. The protein migrates as 11-12 kDa and 43-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    Mucin-1 SDS-PAGE

    Biotinylated Cynomolgus Mucin-1 Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Mucin-1 SEC-MALS

    The purity of Biotinylated Cynomolgus Mucin-1 Protein, His,Avitag (Cat. No. MU1-C82E3) is more than 90% and the molecular weight of this protein is around 35-55 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     Mucin-1 ELISA

    Immobilized Biotinylated Cynomolgus Mucin-1 Protein, His,Avitag (Cat. No. MU1-C82E3) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-Mucin-1 Antibody, Mouse IgG1 with a linear range of 0.05-3 ng/mL (QC tested).

    Protocol

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バックグランド

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants

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医薬品開発の進捗
  • 英語名:

    Mucin-1

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    28 詳細

  • 最新の開発ステージ:

    Phase 2 Clinical

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