user
menu
letter
Sign InRegister
langEnglisharrow
お気に入りに追加

Rat Nectin-4 Protein, Fc Tag (MALS verified)

COADS MS
DS

ユーザーレビュー
製品番号/仕様
価格
Availability
数量
NE4-R5255-100ug
$360.00
In Stock - Delivery in 1-2 business days
NE4-R5255-1mg
$2615.00
In Stock - Delivery in 1-2 business days
総アイテム数 製品金額$ 0
推奨新製品
関連アイテム

製品詳細

  • Synonyms

    NECTIN4, LNIR, PRR4, PVRL4

  • Source

    Rat Nectin-4, Fc Tag (NE4-R5255) is expressed from human 293 cells (HEK293). It contains AA Tyr 28 - Val 348 (Accession # NP_001102546.1).

    Predicted N-terminus: Tyr 28

    Request for sequence

  • Molecular Characterization

    Nectin-4 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 61.1 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.1 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

お客様はこちらも閲覧

データ表示

  • SDS-PAGE

    Nectin-4 SDS-PAGE

    Rat Nectin-4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    Nectin-4 SEC-MALS

    The purity of Rat Nectin-4, Fc Tag (Cat. No. NE4-R5255) is more than 95% and the molecular weight of this protein is around 125-140 kDa verified by SEC-MALS.

    Report

  • Bioactivity-ELISA

    Nectin-4 ELISA

    Immobilized Rat Nectin-4, Fc Tag (Cat. No. NE4-R5255) at 1 μg/mL (100 μL/well) can bind Anti-Nectin-4 Antibody, Mouse IgG1 with a linear range of 0.039-0.625 μg/mL (QC tested).

    Protocol

ユーザーレビュー
コメントを投稿

よくある質問
質問を送信する

  • product

    Can lyophilized proteins remain stable during room-temperature shipping or temporary room-temperature exposure?

    In general, lyophilized proteins remain stable during room-temperature shipping or temporary exposure to room-temperature conditions.


    Many ACROBiosystems recombinant proteins are supplied in lyophilized (freeze-dried) form. The lyophilization process effectively removes moisture from the product, helping reduce degradation-related reactions and improve protein stability during transportation and storage.


    To evaluate the stability of lyophilized proteins under normal temperature conditions, ACROBiosystems conducted a stability study on 11 representative lyophilized protein products at 37°C. The study demonstrated that these proteins maintained good quality stability after storage at 37°C for approximately 20 days. Based on these validation results, temporary room-temperature exposure during shipping or handling is generally not expected to have a significant impact on product quality or downstream application performance.


    To ensure optimal long-term stability, products should be stored according to the storage conditions specified in the product Certificate of Analysis (COA) upon receipt.


    Supporting Document


バックグランド

Nectin-4 (Nectin Cell Adhesion Molecule 4) is a member of the nectin family of immunoglobulin-like cell adhesion molecules. It is highly expressed during embryonic development but shows limited expression in most normal adult tissues. Nectin-4 is overexpressed in a variety of solid tumors, including bladder, breast, lung, pancreatic and ovarian cancers, and has been associated with tumor growth, invasion and metastasis. Studies have shown that Nectin-4 contributes to tumor progression through multiple signaling pathways, including PI3K/Akt signaling. Due to its restricted expression in normal tissues and elevated expression in malignant tumors, Nectin-4 has emerged as an attractive therapeutic target for cancer diagnosis and treatment.

最新の進展

 
医薬品開発の進捗
  • 英語名：

    Nectin-4

  • カテゴリ：

  • 市販の医薬品数：

    1 詳細

  • 治験医薬品数：

    28 詳細

  • 最新の開発ステージ：

    Approved

お問い合わせ
医薬品候補ライセンス
他の関連情報
  • 製品情報
  • 製品詳細
  • お客様はこちらも閲覧
  • データ表示
  • ユーザーレビュー
  • よくある質問
  • 背景