Human Plasma Kallikrein / KLKB1 Protein, His Tag (Pro-form, MALS verified)

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製品番号/仕様
価格
数量
KL1-H52H9-20ug
$310.00
KL1-H52H9-100ug
$905.00
KL1-H52H9-500ug
$3090.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    Fletcher factor, kallikrein B, plasma (Fletcher factor) 1, kininogenin, KLK3 plasma kallikrein, KLKB1, plasma kallikrein heavy chain, plasma kallikrein light chain, Plasma Kallikrein, Plasma Prekallikrein, PPK, KLKB1

  • Source

    Human Plasma Kallikrein/KLKB1, His Tag (KL1-H52H9) is expressed from human 293 cells (HEK293). It contains AA Gly 20 - Ala 638 (Accession # P03952-1).

    Predicted N-terminus: Gly 20

    Request for sequence
  • Molecular Characterization

    Plasma Kallikrein/KLKB1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 71.1 kDa. The protein migrates as 70-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50mM Tris, 150mM NaCl, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping and Storage

    This product is supplied and shipped on dry ice.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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  • SDS-PAGE

    Plasma Kallikrein/KLKB1 SDS-PAGE

    Human Plasma Kallikrein/KLKB1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Plasma Kallikrein/KLKB1 SEC-MALS

    The purity of Human Plasma Kallikrein/KLKB1, His Tag (Cat. No. KL1-H52H9) is more than 90% and the molecular weight of this protein is around 75-90 kDa verified by SEC-MALS.

    Report
  • Bioactivity

    Measured by its ability to cleave a flourogenic peptide substrate Pro-Phe-Arg-7-amido-4-methylcoumarin (PFR-AMC). The specific activity is >1,000 pmol/min/μg (QC tested).

    Protocol

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バックグランド

Human Plasma Kallikrein, a serine protease, is synthesized in the liver and circulates in the plasma by binding to high molecular weight (HMW) kininogen or as a free zymogen. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Plasma kallikrein

  • カテゴリ:

  • 市販の医薬品数:

    4 詳細

  • 治験医薬品数:

    12 詳細

  • 最新の開発ステージ:

    Approved

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