Human Prolactin R / PRLR Protein, His Tag

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製品番号/仕様
価格
数量
PRR-H52Ha-100ug
$310.00
PRR-H52Ha-1mg (250ug X 4)
$2245.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    Prolactin R, PRLR, PRL-R

  • Source

    Human Prolactin R, His Tag (PRR-H52Ha) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Asp 234 (Accession # P16471-1).

    Predicted N-terminus: Gln 25

    Request for sequence
  • Molecular Characterization

    Prolactin R Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 26.3 kDa. The protein migrates as 30-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    Prolactin R SDS-PAGE

    Human Prolactin R, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     Prolactin R ELISA

    Immobilized Human Prolactin, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. PRN-H5257) at 5 μg/mL (100 μL/well) can bind Human Prolactin R, His Tag (Cat. No. PRR-H52Ha) with a linear range of 20-156 ng/mL (QC tested).

    Protocol
  •  Prolactin R ELISA

    Immobilized Human GH, Tag Free at 5 μg/mL (100 μL/well) can bind Human Prolactin R, His Tag (Cat. No. PRR-H52Ha) with a linear range of 0.313-5 μg/mL (Routinely tested).

    Protocol

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バックグランド

As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Prolactin receptor

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    2 詳細

  • 最新の開発ステージ:

    Phase 3 Clinical

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