GMP Human IL-6 Protein

IL-6 (Interleukin-6)​ is a multifunctional cytokine involved in immune regulation and hematopoiesis, acting synergistically with IL-3 and SCF to stimulate early hematopoietic progenitor proliferation. In HSC culture, IL-6 promotes progenitor cell expansion and can support the maintenance of stem and progenitor cell activity. During iPSC differentiation toward HSCs, IL-6 aids in the transition from mesoderm to hematopoietic commitment and enhances the functional output of hematopoietic progenitors, especially in synergy with IL-3 and thrombopoietin.

• Specific HSC Expansion Driver​: Efficiently supports hematopoietic stem cell expansion and hPSC-derived hematopoietic stem and progenitor cell differentiation, validated in multiple clinical trials and cell manufacturing processes.
• Reliable Large-Scale Supply: Ensures batch production capacity, supporting robust and consistent manufacturing scale-up.
• High Lot-to-Lot Consistency​: Ensures reliable and reproducible performance in every batch, supporting scalable applications.

• Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
• End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
• Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
• Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
• Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
• Professional Support: Extensive manufacturing and application expertise to accelerate development.

Val-Pro-Pro-Gly-Glu-Asp-Ser-Lys-Asp-Val-Ala-Ala-Pro-His-Arg
(Routinely tested)

Less than 10 EU/mg, tested by the LAL method in compliance with USP <85> and Ph. Eur. 2.6.14.

<0.5 ng/µg of protein tested by ELISA.

<0.02 ng/μg of protein tested by qPCR.

Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1.

Negative

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with protectants.

Contact us for customized product form or formulation.

2R (13 mm neck finish)

This product is supplied and shipped on blue ice.

Upon receipt, store it immediately at -20°C or lower for long term storage.

Please avoid repeated freeze-thaw cycles.

• -20°C to -70°C for 5 years in lyophilized state;
• -70°C for 12 months under sterile conditions after reconstitution.