GMP Human VCAM-1 Protein, Fc Tag

VCAM1​ (Vascular Cell Adhesion Molecule 1) is a cell surface adhesion molecule belonging to the immunoglobulin superfamily, serving as a key receptor mediating intercellular adhesion and signal transduction. In induced pluripotent stem cell (iPSC)-based T-cell and NK-cell differentiation systems, VCAM1 works in synergy with DLL4 to construct a key signaling combination that mimics the thymic microenvironment, playing a pivotal role in the homing, survival, and lineage-specific differentiation of hematopoietic progenitor cells.

• Unique Clinical-Grade Offering: The only GMP-grade VCAM1 available, validated in multiple clinical trials and cell manufacturing processes.
• Feeder-Free Culture Support: Enables feeder cell-independent culture systems, streamlining T/NK cell production workflows.
• Functional Differentiation Driver: Specifically supports efficient and directed differentiation toward T and NK cell lineages.
• Scalable and Reproducible: Features stringent quality control and high lot-to-lot consistency for seamless transition from research to clinical manufacturing.

• Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
• End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
• Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
• Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
• Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
• Professional Support: Extensive manufacturing and application expertise to accelerate development.

GMP Human VCAM-1 Protein, Fc Tag (GMP-VC1H25) is expressed from human 293 cells (HEK293). It contains AA Phe 25 - Glu 698 (Accession # P19320-1).

Less than 10 EU/mg, tested by the LAL method in compliance with USP <85> and Ph. Eur. 2.6.14.

<5 ppm of protein tested by ELISA.

<0.5 ng/µg of protein tested by ELISA.

<0.02 ng/μg of protein tested by qPCR.

Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1.

Negative

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with protectants.

Contact us for customized product form or formulation.

2R (13 mm neck finish)

This product is supplied and shipped on blue ice.

Upon receipt, store it immediately at -20°C or lower for long term storage.

Please avoid repeated freeze-thaw cycles.

• -20°C to -70°C for 5 years in lyophilized state;
• -70°C for 12 months under sterile conditions after reconstitution.