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B21R

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B21Rバックグランド

Monkeypox is a rare zoonosis caused by monkeypox virus, which has become the most serious orthpoxvirus and consists of complex double stranded DNA. The cases are mostly in central and western Africa. The pathogenesis of monkeypox is that the virus invades the body from respiratory mucosa, multiplies in lymphocytes, and incurs into blood producing transient venereal toxemia. after the virus multiplies in cells, the cells can invade the blood and propagate to the skin of the whole body, causing lesions. The important target protein B21R with key immune dominant epitopes is considered to be the focus of monkeypox virus research.

治験薬に関する情報

英語名	研究コード	研究開発ステージ	会社	適応症	臨床試験
BLU-782	BLU-782; IPN-60130	Phase 2 Clinical	Blueprint Medicines Corp, Ipsen SA	Myositis Ossificans	詳細
Zilurgisertib	INCB-000928; INCB-00928	Phase 2 Clinical	Incyte Corp	Anemia; Polycythemia Vera; Myelodysplastic Syndromes; Kidney Diseases; Ossification, Heterotopic; Multiple Myeloma; Myositis Ossificans; Primary Myelofibrosis; Thrombocythemia, Essential	詳細
KER-047	KER-047	Phase 1 Clinical	National Center For Advancing Translational Sciences	Anemia, Iron-Deficiency; Myositis Ossificans	詳細
Itacnosertib	TP-0184	Phase 1 Clinical	Tolero Pharmaceuticals Inc, Sumitomo Dainippon	Solid tumours; Anemia	詳細
BCX-9250	BCX-9250	Phase 1 Clinical	Biocryst Pharmaceuticals Inc	Myositis Ossificans	詳細

市販薬剤に関する情報

英語名	研究コード	研究開発ステージ	会社	オリジナル製品名	最初に承認をした国	最初の適応症	最初に承認を受けた会社	承認された日付	適応症	臨床試験
Momelotinib Dihydrochloride	CYT-387; GS-0387; GSK-3070785	Approved		Ojjaara, Omjjara	United States	Primary Myelofibrosis; Anemia	Glaxosmithkline Llc, Glaxosmithkline Plc	2023-09-15	Polycythemia; Polycythemia Vera; Anemia; Neoplasms; Myeloproliferative Disorders; Pancreatic Intraductal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Splenomegaly; Thrombocythemia, Essential; Carcinoma, Non-Small-Cell Lung	詳細