Glycoprotein H & Glycoprotein L

Epstein-Bar Virus (EBV), belonging to gamma herpesvirus, is one of the most common human viruses which widely spread all over the world. EBV is the primary cause of infectious mononucleosis (IM) and is found to be related to several types of cancers. Although gp350 is the most abundant glycoprotein on viruses’ surfaces, the research on using gp350 as vaccine antigen progresses slowly making glycoprotein H and glycoprotein L heterodimer (gH/gL) be considered as a candidate for vaccine development. gH/gL plays an important role in assisting the fusion process with the binding of Ephrin type-A receptor 2 (EphA2).