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COADS MSDS

GMP Monoclonal Anti-Human CD3 Antibody (OKT3)

DMF
Premium grade (Pre-GMP) version CDE-M120a is now available for seamless transition.
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COADS MSDS
Cat. No. / Size
Price
Availability
Qty
GMP-MC0323-500ug
$1,080.00
In Stock - Delivery in 2-3 weeks
GMP-MC0323-1mg (500ug X 2)
$1,730.00
In Stock - Delivery in 2-3 weeks
GMP-MC0323-10mg (500ug X 20)
$12,110.00
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GMP-MC0323
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Product Details
Performance Data
Reviews & Citations
Important Statement
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
GMP Platform Advantages
  • Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
  • End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
  • Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
  • Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
  • Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
  • Professional Support: Extensive manufacturing and application expertise to accelerate development.
Source

HEK293 cells-expressed human GMP Monoclonal Anti-Human CD3 Antibody (OKT3).

Isotype

Mouse IgG2a, Kappa

Specificity

This product is a specific antibody specifically reacts with CD3 epsilon.

Endotoxin

Less than 2 EU/mg, tested by the LAL method in compliance with USP <85> and Ph. Eur. 2.6.14.

Protein A

<5 ppm of protein tested by ELISA.

Host Cell Protein

<0.5 ng/μg of protein tested by ELISA.

Host Cell DNA

<0.02 ng/μg of protein tested by qPCR.

Purity

>95% as determined by SDS-PAGE.

>95% as determined by SEC-HPLC.

Sterility

Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1.

Mycoplasma

Negative

Formulation

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with protectants.

Contact us for customized product form or formulation.

Vial Specification

2R (13 mm neck finish)

Shipping

This product is supplied and shipped with dry ice, please inquire the shipping cost.

Storage

For long term storage, the product should be stored at liquid state at -70°C.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • 2-8°C for 12 months under sterile conditions;
  • -70°C for 5 years.
ACRO Quality Management System

Background

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.