Recombinant Monoclonal Anti-CD45(LCA) Antibody, Rabbit (1C3)

Product Details

Background
Recombinant Monoclonal Anti-CD45(LCA) Antibody, Rabbit (1C3) is a CD45(LCA) primary antibody for IHC application. Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Host Species	Rabbit
Isotype	Rabbit IgG, Rabbit Kappa
Clone	1C3
Application	IHC-P
Dilution Ratio	1: 500 - 1: 2000
Form	Liquid
Clonality	Monoclonal
Reactivity	Human
Synonyms	PTPRC, CD45, GP180, LCA, T200
Concentration	0.9~1.1 mg/ml
Specificity	React with CD45(LCA) protein on the membrane of target cell/tissue
Purification Tech	Protein A
Preservation	PBS, BSA, Glycerol

Experiment Protocol
LEICA Experiment Protocol
Storage
Shipped at 4°C, Blue Ice. Store at +4°C for short term (1-2 weeks). Store at -20°C for long term.
Avoid freeze / thaw cycle. Upon delivery aliquot.
ACRO Quality Management System

Sample Staining Data
Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S261 at 1:1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

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