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Recombinant Monoclonal Anti-Claudin-18.2 Antibody, Mouse (3B10) is a Claudin-18.2 primary antibody for IHC application. The Claudin-18.2 (CLDN 18.2) protein, an isoform of Claudin 18, a member of the tight junction protein family, is a highly selective biomarker with limited expression in normal tissues and often abnormal expression during the occurrence and development of various primary malignant tumors, such as gastric cancer/gastroesophageal junction (GC/GEJ) cancer, breast cancer, colon cancer, liver cancer, head and neck cancer, bronchial cancer and non-small-cell lung cancer. Claudin-18.2 participates in the proliferation, differentiation and migration of tumor cells. Recent studies have identified Claudin-18.2 expression as a potential specific marker for the diagnosis and treatment of these tumors.
Host Species | Mouse |
Isotype | Mouse IgG1, Mouse Kappa |
Clone | 3B10 |
Application | IHC-P |
Dilution Ratio | 1: 500 - 1: 2000 |
Form | Liquid |
Clonality | Monoclonal |
Reactivity | Human |
Synonyms | CLDN 18.2 |
Concentration | 0.6~0.9 mg/ml |
Specificity | React with Claudin 18.2 protein on the membrane of target cell/tissue; No cross reactivity with Claudin 18.1 |
Purification Tech | Protein G |
Preservation | PBS, 10% Trehalose (pH7.4) |
Shipped at 4°C, Blue Ice. Store at +4°C for 14 days. Store at -20°C for long term.
Avoid freeze / thaw cycle. Upon delivery aliquot.