ADC Isotype Control Mouse IgG2a (MMAE)

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Cat. No. / Size
Price
Qty
DNP-BM487-100ug
$195.00
DNP-BM487-1mg
$790.00
ETA of in-stock products:2 business days

Product Details

  • Source

    ADC Isotype Control Mouse IgG2a (MMAE) is a recombinant mouse monoclonal antibody expressed in HEK293 cells.

  • Antibody Type

    Recombinant Monoclonal

  • Isotype

    Mouse IgG2a, Kappa

  • Host Species

    Mouse

  • Purification

    Protein A purified / Protein G purified.

  • Aggregation

    Less than 5%, as determined by SEC-MALS.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Background

MMAE (Monomethyl auristatin E) is a synthetic microtubule inhibitor. It binds to tubulin to prevent microtubule polymerization, inducing tumor cell cycle arrest and apoptosis. As a highly toxic payload commonly used in ADCs, it has excellent plasma stability; when conjugated to antibodies, it can precisely kill target cells and is widely applied in the R&D of ADC drugs for hematological malignancies and solid tumors.

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