HRP conjugated Monoclonal Anti-Human IgG3 Fc Antibody, Mouse IgG2a (2B7)

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Cat. No. / Size
Price
Qty
IG3-HMY2179-100ug
$220.00
IG3-HMY2179-1mg
$1600.00
ETA of in-stock products:2 business days

Product Details

  • Source

    HRP conjugated Monoclonal Anti-Human IgG3 Fc Antibody, Mouse IgG2a (2B7) is a mouse monoclonal antibody recombinantly expressed in HEK293 cells.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    2B7

  • Isotype

    Mouse IgG2a, Kappa

  • Host Species

    Mouse

  • Reactivity

    Human, Cynomolgus Monkey (minimal cross-reactivity)

  • Immunogen

    Recombinant Human IgG3 Fc is expressed from human 293 cells

  • Conjugate

    HRP Labeled

  • Specificity

    Specifically reacts with the Fc region of human IgG3, with minimal cross-reactivity to other human IgG isotypes and Cynomolgus IgG1.

  • Cross Verification

    Strong reactivity: Human IgG3.
    Minimal cross-reactivity (<1%): Cynomolgus IgG1, Human IgG1, Human IgG2, Human IgG4 and their engineered variants.
    No cross-reactivity: Rabbit IgG, Rat IgG, Mouse IgG1/IgG2a/IgG2b, Human IgA1, Human IgA2, Human IgM.

  • Purification

    Protein A purified / Protein G purified.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 24 months in lyophilized state;
    2. -70°C for 12 months after reconstitution.
    3. 2-8 °C for 1 week after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

     IgG3 Fc ELISA

    Immobilized Human IgG3 Kappa Isotype Control (mAb) (Cat. No. DNP-M915) at 1 μg/mL (100 μL/well) can bind HRP conjugated Monoclonal Anti-Human IgG3 Fc Antibody, Mouse IgG2a (2B7) (Cat. No. IG3-HMY2179) with a linear range of 0.1-4 ng/mL (QC tested).

    Protocol

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Background

Immunoglobulin G3 (IgG3) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. Ig gamma-3 chain C region (IgG3-Fc / IGHG3) contains two constant regions of IgG3 H chain (CH2, CH3).

Recent Advances

 
Drug Development Progress
  • English Name:

    Immunoglobulin G

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  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    7 Details

  • Highest Development Stage:

    Approved

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