Mogengel Matrix IPSC Level (Acro Certified)

Mogengel Matrix IPSC Level is intended to be used as a supplement to specified media to culture stem cells including human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSCs). Mogengel Matrix IPSC Level provides the reproducibility and consistency required for trophoblast culture of hESCs and iPSCs and can be used for in vivo differentiation studies such as teratoma formations.

• Basement membranes are comprised of continuous sheets of a specialized extracellular matrix. It acts an interface between various types of cells, including muscle, neuronal, epithelial, or endothelial cells, along with adjacent stroma. Basement membranes are an essential part in the organization of tissues forming the scaffolding and support for cellular growth and cell layers. They also affect a variety of cellular mechanisms such as adhesion, migration, proliferation, and differentiation. Basement membranes are selectively degraded and regenerated during development and wound healing, forming the base scaffold for tissue reconstruction. Basement membranes also act as a major barrier to invasion by metastatic tumor cells.
• Mogengel Matrix IPSC Level is a soluble form of basement membrane that is purified from gene-edited mouse tumor cells grown in LDEV-free mouse populations. Reconstitution into the original basement membrane form occurs at 37℃ and is mainly comprised of laminin, collagen IV, entactin, and heparin sulfate proteoglycan.