GMP Human Activin A / INHBA Protein

Activin A, a pivotal member of the TGF-β superfamily of signaling proteins, is fundamentally involved in regulating embryonic development and cellular differentiation processes. In the context of stem cell differentiation, its primary role is to direct pluripotent stem cells towards a definitive endoderm fate, which is the essential germ layer that gives rise to the pancreas and other internal organs.

• Specific Endoderm Differentiation Driver​: Efficiently supports stem cell differentiation into definitive endoderm lineages, including pancreatic beta islet cells and other endodermal cell types.
• Reliable Large-Scale Supply: Ensures consistent batch production capacity exceeding 1 gram, supporting robust scale-up for manufacturing.
• Stringent Safety Profile​: Incorporates comprehensive virus testing, validation, and ultra-low endotoxin levels (< 0.01 EU/μg) to meet stringent quality standards.
• Cost-Effective and Convenient​: Achieves up to 50% cost savings versus conventional alternatives, with simplified reconstitution in water instead of hydrochloric acid for ease of use.

• Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
• End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
• Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
• Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
• Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
• Professional Support: Extensive manufacturing and application expertise to accelerate development.

Gly-Leu-Glu-Cys-Asp-Gly-Lys-Val-Asn-Ile-Cys-Cys-Lys-Lys-Gln
(Routinely tested)

Less than 10 EU/mg, tested by the LAL method in compliance with USP <85> and Ph. Eur. 2.6.14.

<0.5 ng/µg of protein tested by ELISA.

<0.02 ng/μg of protein tested by qPCR.

Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1.

Negative

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with protectants.

Contact us for customized product form or formulation.

2R (13 mm neck finish)

This product is supplied and shipped on blue ice.

Upon receipt, store it immediately at -20°C or lower for long term storage.

Please avoid repeated freeze-thaw cycles.

• -20°C to -70°C for 5 years in lyophilized state;
• -70°C for 12 months under sterile conditions after reconstitution.