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Product Details
Synonyms
Activin receptor type IIA, ACTRIIA
Source
Human / Cynomolgus Activin RIIA Protein, Fc Tag (ACA-H5269) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Pro 135 (Accession # P27037-1). In the region Ala 20 - Pro 135, the amino acid sequences of Human and Cynomolgus Activin RIIA are identical.
Predicted N-terminus: Pro
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 39.9 kDa. The protein migrates as 50-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
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Performance Data
SDS-PAGE
Human / Cynomolgus Activin RIIA Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
Bioactivity-ELISA
Immobilized Human Activin A Protein, Tag Free (Cat. No. ACA-H421b) at 5 μg/mL (100 μL/well) can bind Human / Cynomolgus Activin RIIA / ACVR2A Protein, Fc Tag (Cat. No. ACA-H5269) with a linear range of 0.2-8 ng/mL (QC tested).
Protocol
Immobilized Human / Cynomolgus Activin RIIA Protein, Fc Tag (Cat. No. ACA-H5269) at 1 μg/mL (100 μL/well) can bind Bimagrumab with a linear range of 0.1-3 ng/mL (Routinely tested).
Protocol
Customer Reviews Writing Reviews
L***i2024-11-05
LikesWe have been purchasing Activin products from Acro for a few years now and have always appreciated the quality and consistency. We were excited to see that biotinylated options are now available, as they fit our research needs perfectly. Acro's reliable service keeps us coming back as satisfied customers, and we look forward to using these new products.- A***z2022-06-15 LikesThe product quality was excellent. The technical services was better than all competitors and the logistics speed was very fast. All in all, a fantastic product and a fantastic company.
Background
Recent Advances
Drug Development Progress- English Name：
Activin receptor type-2A
- Category：
- Approved Drugs：
0 Details
- Drugs in Clinical Trials：
4 Details
- Highest Development Stage：
Phase 2 Clinical
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