Human ALK-7 Protein, Fc Tag (MALS verified)

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Cat. No. / Size
Price
Qty
AL7-H5253-100ug
$360.00
AL7-H5253-1mg (500ug X 2)
$2615.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    ALK-7, ACTR-IC, ACVR1C

  • Source

    Human ALK-7 Protein, Fc Tag (AL7-H5253) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Glu 113 (Accession # Q8NER5-1).

    Predicted N-terminus: Glu 21

    Request for sequence
  • Molecular Characterization

    ALK-7 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 36.5 kDa. The protein migrates as 43-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    ALK-7 SDS-PAGE

    Human ALK-7 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    ALK-7 SEC-MALS

    The purity of Human ALK-7 Protein, Fc Tag (Cat. No. AL7-H5253) is more than 90% and the molecular weight of this protein is around 75-105 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     ALK-7 ELISA

    Immobilized Human ALK-7 Protein, Fc Tag (Cat. No. AL7-H5253) at 1 μg/mL (100 μL/well) can bind Rabbit anti-Homo sapiens (Human) ACVR1C Polyclonal antibody, Rabbit IgG with a linear range of 0.0005-0.25 μg/mL (QC tested).

    Protocol

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Background

ALK-7, also known as ACVR1C , is a Type I receptor for the TGF-beta family of signaling molecules. Upon ligand binding, it initiates intracellular signaling by phosphorylating cytoplasmic SMAD transcription factors. These activated SMADs then translocate to the nucleus to regulate gene expression, either directly or in complex with other transcription factors.

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