Human Bcl-x / BCL2L1 Protein, GST Tag

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製品番号/仕様
価格
数量
BC1-H513a-100ug
$260.00
BC1-H513a-1mg
$1545.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    BCL2L1, Bcl-XL, Bcl2-L-1, BCL-XL, S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, bcl-xS

  • Source

    Human Bcl-x, GST Tag (BC1-H513a) is expressed from E. coli cells. It contains AA Ser 2 - Arg 212 (Accession # AAH19307).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    Bcl-x Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a GST tag at the N-terminus.

    The protein has a calculated MW of 50.6 kDa. The protein migrates as 45-50 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 100 mM NaCl, 10 mM GSH, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    Bcl-x SDS-PAGE

    Human Bcl-x, GST Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

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バックグランド

Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Apoptosis regulator Bcl-X

  • カテゴリ:

  • 市販の医薬品数:

    1 詳細

  • 治験医薬品数:

    8 詳細

  • 最新の開発ステージ:

    Approved

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