GMP Human BMP-4 / BMP2B Protein

Bone Morphogenetic Protein 4 (BMP4), a key member of the TGF-β superfamily binds to cell surface receptors to activate the Smad signaling pathway. Notably, in stem cells, BMP4 plays a pivotal role in inducing the differentiation of mesenchymal stem cells into osteoblasts, guiding their fate towards bone-forming cells. It is also involved in various physiological processes such as embryonic development, tissue repair, and maintaining tissue homeostasis.

• Specific Differentiation Driver: Highly supports hPSC differentiation towards mesoderm lineages, including hematopoietic stem cells (HSC), T cells, and NK cells.
• Seamless Clinical Translation: GMP grade enables a reliable and compliant transition from R&D to clinical trials and manufacturing.
• Significant Cost Efficiency​: Achieves substantial savings, reducing production costs by up to 50% in comparison to conventional alternatives.
• High Lot-to-Lot Consistency​: Ensures reliable and reproducible performance in every batch, supporting scalable applications.

• Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
• End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
• Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
• Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
• Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
• Professional Support: Extensive manufacturing and application expertise to accelerate development.

Ser-Pro-Lys-His-His-Ser-Gln-Arg-Ala-Arg-Lys-Lys-Asn-Lys-Asn-Cys
(Routinely tested)

Less than 10 EU/mg, tested by the LAL method in compliance with USP <85> and Ph. Eur. 2.6.14.

<0.5 ng/µg of protein tested by ELISA.

<0.02 ng/μg of protein tested by qPCR.

Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1.

Negative

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in 20 mM Citric acid, pH2.2 with protectants.

Contact us for customized product form or formulation.

2R (13 mm neck finish)

This product is supplied and shipped on blue ice.

Upon receipt, store it immediately at -20°C or lower for long term storage.

Please avoid repeated freeze-thaw cycles.

• -20°C to -70°C for 5 years in lyophilized state;
• -70°C for 12 months under sterile conditions after reconstitution.