Human FGF19 Protein, His Tag

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製品番号/仕様
価格
数量
FG9-H51H3-100ug
$360.00
FG9-H51H3-1mg (100ug X 10)
$2615.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    FGF19, FGF-19, Fibroblast growth factor 19

  • Source

    Human FGF19, His Tag (FG9-H51H3) is expressed from E. coli cells. It contains AA Leu 25 - Lys 216 (Accession # O95750-1).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    FGF19 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 23.4 kDa. The protein migrates as 28 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.3 M NaCl, 0.3 M Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    FGF19 SDS-PAGE

    Human FGF19, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • Bioactivity-BLI

     FGF19 BLI

    Loaded Human FGF R4, Fc Tag (Cat. No. FG4-H5253) on Protein A Biosensor, can bind Human FGF19, His Tag (Cat. No. FG9-H51H3) with an affinity constant of 63.5 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

    Protocol
  •  FGF19 BLI

    Loaded Human FGF19, His Tag (Cat. No. FG9-H51H3) on HIS1K Biosensor, can bind Human FGF R4, Fc Tag (Cat. No. FG4-H5253) with an affinity constant of 16.6 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

    Protocol

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バックグランド

Fibroblast growth factor (FGF)19 is the first members of a new subfamily of FGFs and could act as hormones. During fetal life, FGF15/19 is involved in organogenesis, affecting the development of the ear, eye, heart, and brain. FGFs–FGFRs are involved in regulation of many biological processes such as embryonic development, cell proliferation, differentiation, and tissue repair. The dysregulation of FGF–FGFR was observed in different types of diseases, disorders, and cancers. Notably, aberrant expression of FGF19/FGFR4 contributes to Hepatocellular Carcinoma progression.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Fibroblast growth factor 19

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    2 詳細

  • 最新の開発ステージ:

    Phase 2 Clinical

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