Human FGF19 Protein, Mouse IgG2a Fc Tag

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FG9-H5254-100ug
$360.00
In Stock - Delivery in 2-3 business days
FG9-H5254-1mg
$2615.00
In Stock - Delivery in 2 weeks
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    FGF19, FGF-19, Fibroblast growth factor 19

  • Source

    Human FGF19 Protein, Mouse IgG2a Fc Tag (FG9-H5254) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Lys 216 (Accession # O95750-1).

    Predicted N-terminus: Leu 25

    Request for sequence
  • Molecular Characterization

    FGF19 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a mouse IgG2a Fc tag at the C-terminus.

    The protein has a calculated MW of 48.3 kDa. The protein migrates as 53-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    FGF19 SDS-PAGE

    Human FGF19 Protein, Mouse IgG2a Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

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バックグランド

Fibroblast Growth Factor 19 (FGF19) is a hormone belonging to the FGF family, encoded by the FGF19 gene. It is primarily synthesized and secreted in the ileum in response to bile acid absorption, acting as a ligand for the farnesoid X receptor (FXR). FGF19's core function is to exert negative feedback on hepatic bile acid synthesis by binding to the Fibroblast Growth Factor Receptor 4 (FGFR4)/Klotho-β complex in the liver, thereby inhibiting cholesterol 7α-hydroxylase (CYP7A1). Additionally, it plays a role in glucose and lipid metabolism. Its mouse ortholog is FGF15, and they are often referred to collectively as FGF15/19. Altered FGF19 levels are implicated in chronic bile acid diarrhea and certain metabolic disorders.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Fibroblast growth factor 19

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    2 詳細

  • 最新の開発ステージ:

    Phase 2 Clinical

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