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Fibronectin, a large glycoprotein, has multiple key functions. It mediates cell adhesion by binding to cell-surface integrins, enabling cells to attach to the extracellular matrix, which is vital for cell migration during processes like wound healing and embryonic development. In the bloodstream, it stabilizes blood clots by binding to fibrin. It could support mesenchymal stem cell attachment and proliferation.
GMP Recombinant Human Fibronectin fragment (GMP-FINH18) is expressed from E. coli cells. It contains AA Pro 1361 - Ser 1637 & Ala 1812 - Thr 2107 (Accession # P02751-15).
Predicted N-terminus: Met
This protein carries no "tag".
The protein has a calculated MW of 62.6 kDa. The protein migrates as 60 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
Less than 10 EU/mg, tested by the LAL method in compliance with USP <85> and Ph. Eur. 2.6.14.
<0.5 ng/µg of protein tested by ELISA.
<0.02 ng/μg of protein tested by qPCR.
Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1.
Negative
>95% as determined by SDS-PAGE.
>90% as determined by SEC-HPLC.
Supplied as 0.2 μm filtered solution in 12.5 mM Citric acid, pH6.2 with protectants.
Contact us for customized product form or formulation.
6R (20 mm neck finish)
This product is supplied and shipped on dry ice.
Please avoid repeated freeze-thaw cycles.