Human / Mouse / Rat GDF-8 Protein, Tag Free

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製品番号/仕様
価格
数量
GD8-H5344-50ug
$370.00
GD8-H5344-500ug
$2470.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    GDF-8, Myostatin, GDF8, MSTN, Growth, differentiation factor 8

  • Source

    Human / Mouse / Rat GDF-8 Protein, Tag Free (GD8-H5344) is expressed from CHO cells. It contains AA Asp 267 - Ser 375 (Accession # O14793). In the region Asp 267 - Ser 375, the amino acid sequences of Human, Mouse and Rat GDF-8 are identical.

    Predicted N-terminus: Asp 267

    Request for sequence
  • Molecular Characterization

    GDF-8 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries no "tag".

    The protein has a calculated MW of 12.4 kDa. The protein migrates as 12.0 kDa under reducing (R) condition, and 11 kDa and 25 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM HAC, pH3.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    GDF-8 SDS-PAGE

    Human / Mouse / Rat GDF-8 Protein, Tag Free on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     GDF-8 ELISA

    Immobilized Human / Mouse / Rat GDF-8 Protein, Tag Free (Cat. No. GD8-H5344) at 1 μg/mL (100 μL/well) can bind Biotinylated Human Activin RIIB Protein, Fc,Avitag (Cat. No. ACB-H82F3) with a linear range of 0.1-8 ng/mL (QC tested).

    Protocol
  •  GDF-8 ELISA

    Immobilized Human / Mouse / Rat GDF-8 Protein, Tag Free (Cat. No. GD8-H5344) at 2 μg/mL (100 μL/well) can bind Human Follistatin Protein, Fc Tag (Cat. No. FON-H5256) with a linear range of 1-31 ng/mL (Routinely tested).

    Protocol
  •  GDF-8 ELISA

    Immobilized Human / Mouse / Rat GDF-8 Protein, Tag Free (Cat. No. GD8-H5344) at 1 μg/mL (100 μL/well) can bind Human Activin RIIB Protein, Fc Tag (Cat. No. ACB-H5254) with a linear range of 0.1-2 ng/mL (Routinely tested).

    Protocol

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バックグランド

Growth differentiation factor 8 (GDF8), also known as myostatin, is a unique member of the transforming growth factor-β superfamily that is expressed in human granulosa cells and has important roles in regulating a variety of ovarian functions. GDF8 acts as a negative regulator of skeletal muscle growth and differentiation. In addition to the expression in the musculoskeletal system, GDF8 is also expressed in various tissues, including the reproductive system.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Growth/differentiation factor 8

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    8 詳細

  • 最新の開発ステージ:

    NDA/BLA

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