Human GSK-3beta / GSK-3β Protein, His Tag (active enzyme, MALS verified)

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製品番号/仕様
価格
数量
GSB-H5545-20ug
$390.00
GSB-H5545-500ug
$3525.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    GSK3B, Glycogen synthase kinase-3 beta

  • Source

    Human GSK-3beta, His Tag (GSB-H5545) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Thr 420 (Accession # P49841-1).

    Predicted N-terminus: Met

    Request for sequence
  • Molecular Characterization

    GSK-3beta Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 48.8 kDa. The protein migrates as 49-53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with glycerol as protectant.

    Contact us for customized product form or formulation.

  • Shipping and Storage

    This product is supplied and shipped on dry ice.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    GSK-3beta SDS-PAGE

    Human GSK-3beta, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    GSK-3beta SEC-MALS

    The purity of Human GSK-3beta, His Tag (Cat. No. GSB-H5545) is more than 95% and the molecular weight of this protein is around 48-65 kDa verified by SEC-MALS.

    Report
  • Bioactivity

    The specific activity of GSK-3beta was determined to be >120 pmol/min/ug by ADP-Glo™ Kinase Assay using a synthetic substrate (YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE) (QC tested).

    Protocol

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バックグランド

Glycogen synthase kinase-3 (GSK-3) is a pivotal molecule in the development of Alzheimer's disease (AD). GSK-3beta is involved in the formation of paired helical filament (PHF)-tau, which is an integral component of the neurofibrillary tangle (NFT) deposits that disrupt neuronal function, and a marker of neurodegeneration in AD.

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医薬品開発の進捗
  • 英語名:

    Glycogen synthase kinase-3 beta

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    5 詳細

  • 最新の開発ステージ:

    Phase 3 Clinical

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