Human Her2 / ErbB2 (196-319) Protein, Fc Tag (MALS verified)

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製品番号/仕様
価格
数量
HE2-H5256-100ug
$315.00
HE2-H5256-1mg (500ug X 2)
$2245.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    ERBB2, CD340, HER-2, neu, HER2, MLN19, NEU, NGL, TKR1

  • Source

    Human Her2 (196-319) Protein, Fc Tag (HE2-H5256) is expressed from human 293 cells (HEK293). It contains AA Ser 196 - Asn 319 (Accession # P04626-1).

    Request for sequence
  • Molecular Characterization

    Her2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 39.8 kDa. The protein migrates as 42-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    Her2 SDS-PAGE

    Human Her2 (196-319) Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Her2 SEC-MALS

    The purity of Human Her2 (196-319) Protein, Fc Tag (Cat. No. HE2-H5256) is more than 90% and the molecular weight of this protein is around 80-100 kDa verified by SEC-MALS.

    Report

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バックグランド

Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Receptor protein-tyrosine kinase erbB-2

  • カテゴリ:

  • 市販の医薬品数:

    47 詳細

  • 治験医薬品数:

    238 詳細

  • 最新の開発ステージ:

    Approved

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