Human IDS Protein, His Tag (active enzyme, MALS verified)

Iduronate 2-sulfatase (IDS) is a lysosomal enzyme essential for the degradation of glycosaminoglycans (GAGs), specifically heparan sulfate and dermatan sulfate.

Mutations or deficiency in the IDS gene cause Hunter syndrome (Mucopolysaccharidosis type II, MPS II), an X-linked lysosomal storage disorder characterized by the toxic accumulation of GAGs in tissues and organs.

In drug development, recombinant IDS proteins are critical reagents. They are mainly used to support Enzyme Replacement Therapy (ERT), gene therapy, and blood-brain barrier (BBB) crossing drug pipelines, specifically for in vitro enzyme activity assays, cellular uptake studies, and immunogenicity (ADA/NAb) screening.