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COADS MSDS

GMP Human IL-18 Protein

DMF
Premium grade (Pre-GMP) version IL8-H5114 is now available for seamless transition.
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COADS MSDS
Cat. No. / Size
Price
Availability
Qty
GMP-L18H16-50ug
$1,355.00
In Stock - Delivery in 1-2 business days
GMP-L18H16-1mg (50ug X 20)
$11,345.00
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GMP-L18H16-10mg (50ug X 200)
$79,415.00
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GMP-L18H16
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Product Details
Performance Data
Reviews & Citations
Important Statement
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Product Features and Advantages
  • Wide-ranging functions: Facilitates activating and enhancing IFN-γ production and cytotoxicity in NK cell culture, while serving as an auxiliary cytokine to boost effector functions in TIL, γδT, and T cell cultures.
  • High Performance: Exhibits superior application activity and has become the top choice for numerous pharmaceutical enterprises.
  • Comprehensive Safety Assurance: E. coli expressed system and the Master Cell Bank (MCB) implemented with 7 standardized detection items, animal origin-free (AOF) production process.
  • Lot-to-Lot Consistency: Achieved through a stable cell line and robust process, ensuring reliable performance from research to clinical manufacturing.
GMP Platform Advantages
  • Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
  • End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
  • Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
  • Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
  • Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
  • Professional Support: Extensive manufacturing and application expertise to accelerate development.
Source

GMP Human IL-18 Protein (GMP-L18H16) is expressed from E. coli cells. It contains AA Tyr 37 - Asp 193 (Accession # Q14116).

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries no "tag".

The protein has a calculated MW of 18.2 kDa. The protein migrates as 17 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

N-terminal Sequence Analysis

Tyr-Phe-Gly-Lys-Leu-Glu-Ser-Lys-Leu-Ser-Val-Ile-Arg-Asn-Leu
(Routinely tested)

Endotoxin

Less than 10 EU/mg, tested by the LAL method in compliance with USP <85> and Ph. Eur. 2.6.14.

Host Cell Protein

<0.5 ng/µg of protein tested by ELISA.

Host Cell DNA

<0.02 ng/μg of protein tested by qPCR.

Sterility

Sterility testing was performed using the membrane filtration method in compliance with USP <71> and Ph. Eur. 2.6.1.

Mycoplasma

Negative

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with protectants.

Contact us for customized product form or formulation.

Vial Specification

2R (13 mm neck finish)

Shipping and Storage

This product is supplied and shipped on blue ice.

Upon receipt, store it immediately at -20°C or lower for long term storage.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 5 years in lyophilized state;
  • -70°C for 12 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Interleukin-18 (IL-18) is a potent proinflammatory cytokine that induces interferon-γ (IFN-γ) production from T helper type 1 (Th1) cells and natural killer (NK) cells, particularly in the presence of IL-12. IL-18 also participates in the developmental regulation of Th1 cells and mediates Fas-mediated cytotoxicity. Suppression of IL-18 activity is being investigated for the treatment of chronic inflammatory diseases such as Crohn's disease and rheumatoid arthritis. IL-18 exerts its biological functions by inducing heterodimerization of the two subunits of its receptor, IL-18Rα and IL-18Rβ. These subunits share structural homology with members of the IL-1 receptor superfamily.