Mouse IL-31 RA Protein, Fc Tag (BLI verified)

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ILA-M5254-100ug
$395.00
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ILA-M5254-1mg (500ug X 2)
$2,620.00
In Stock - Delivery in 2 weeks
ILA-M5254
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Synonyms

IL-31 RA, IL-31RA, hGLM-R, CRL3, GPL, ZcytoR17, GLM-R, IL-31R-alpha, Gp130-like receptor

Source

Mouse IL-31 RA Protein, Fc Tag (ILA-M5254) is expressed from human 293 cells (HEK293). It contains AA Val 19 - Thr 499 (Accession # Q8K5B1-1).

Predicted N-terminus: Val 19

Molecular Characterization

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 81.6 kDa. The protein migrates as 110-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.

バックグランド

Interleukin-31 receptor subunit alpha (IL-31RA) is a type I transmembrane protein that heterodimerizes with the Oncostatin M receptor (OSMR) to form the functional receptor complex for IL-31. Upon ligand binding, IL-31RA activates downstream signaling cascades, predominantly the JAK/STAT pathway. Expressed on cutaneous sensory neurons, keratinocytes, and various immune cells, IL-31RA plays a critical role in neuro-immune crosstalk.