GMP Human Laminin 511 Protein

Laminin 511 E8 (LN511-E8) is a recombinant human protein that provides a defined surface for the in vitro feeder-free culture of multiple human pluripotent stem cells (PSCs). As a truncated form of laminin 511, LN511-E8 is a functionally minimal form that retains the full capability for binding to integrins. LN511-E8 has been proven to maintain normal growth characteristics and stemness in multiple PSC lines without simultaneous differentiation, which includes ESC, iPSC, MSC, etc. In addition, LN511-E8 has been demonstrated to support PSC growth for >10 passages without any signs of karyotypic abnormalities and to maintain the ability of PSCs to differentiate into all three germ line lineages. As published by Takamichi Miyazaki et al., the LN511-E8 variant of laminin 511 shows higher efficiency for supporting the adhesion of dissociated cells than did wild-type laminin 511 which makes it a cost-effective choice.
High-quality products and regulatory support files are essential for the smooth transition from preclinical research & development to cell therapy clinical study. Designed for clinical research, GMP Laminin 511 is manufactured by an animal-free process in a GMP-compliant facility. A full battery of QC testing is implemented to ensure product quality, including purity, bioactivity, sterility, mycoplasma, endotoxin, etc. GMP Laminin 511 protein (GMP-LA1H25) is the GMP version of laminin 511 protein premium grade (LA8-H5283L), and they have the same performance for a seamless transition.
This product is designed and developed utilizing our proprietary AI technology, which is protected by patent rights. We retain full commercial rights to this product.

• Excellent Performance​: Enables rapid expansion and superior stemness maintenance of hPSCs with strong, uniform adhesion support.
• Superior Biological Functionality: LN511-E8 fragment enhances cell adhesion, supports differentiation, and mimics in vivo signaling via α6β1 integrin binding.
• Comprehensive Safety Assurance: ECACC-compliant HEK293 host cell origin and comprehensive testing (28 items), animal-origin-free (AOF) production process, dual virus reduction measures, and comprehensive viral clearance validation.
• Defined & Consistent Quality​: Produced from a stable cell line with a robust purification process and stringent QC for exceptional lot-to-lot consistency.

• Quality Assurance: Global QMS with comprehensive and stringent QC release criteria.
• End-to-End GMP Compliance: Full manufacturing and QC under a cGMP system.
• Comprehensive Control of Adventitious Agents: Stringent biosafety from cell banks to final release.
• Comprehensive Regulatory Support: Includes RSF and DMF to meet global requirements.
• Resilient Supply Chain: Intelligent modular facilities ensure a stable global supply.
• Professional Support: Extensive manufacturing and application expertise to accelerate development.

HEK293

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with protectants.

Contact us for customized product form or formulation.

2R (13 mm neck finish)

This product is supplied and shipped with dry ice, please inquire the shipping cost.

For long term storage, the product should be stored at liquid state at -20℃ or below.

Please avoid repeated freeze-thaw cycles.

• 2-8°C for 6 months under sterile conditions;
• -20°C or below for 3 years.