Mouse LTBR / TNFRSF3 Protein, His Tag (MALS verified)

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製品番号/仕様
価格
数量
LTR-M52H3-100ug
$415.00
LTR-M52H3-1mg (500ug X 2)
$2615.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    LTBR, D12S370, TNFCR, TNFR3, TNFRSF3, TNFRIII

  • Source

    Mouse LTBR Protein, His Tag (LTR-M52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Leu 223 (Accession # P50284).

    Predicted N-terminus: Gln 31

    Request for sequence
  • Molecular Characterization

    LTBR Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 23.6 kDa. The protein migrates as 28-38 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    LTBR SDS-PAGE

    Mouse LTBR Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    LTBR SEC-MALS

    The purity of Mouse LTBR Protein, His Tag (Cat. No. LTR-M52H3) is more than 90% and the molecular weight of this protein is around 23-35 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     LTBR ELISA

    Immobilized Mouse LTBR Protein, His Tag (Cat. No. LTR-M52H3) at 5 μg/mL (100 μL/well) can bind Human LIGHT Protein, Fc Tag (Cat. No. LIT-H5269) with a linear range of 0.06-2 ng/mL (QC tested).

    Protocol
  • Bioactivity-SPR

     LTBR SPR

    Mouse LTBR Protein, His Tag (Cat. No. LTR-M52H3) immobilized on CM5 Chip can bind Human LIGHT Protein, Fc Tag (Cat. No. LIT-H5269)with an affinity constant of 0.255 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

    Protocol

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バックグランド

Lymphotoxin-beta receptor (LTBR) is also known as Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), Tumor necrosis factor receptor type III (TNF-RIII), which is a single-pass type I membrane protein containing four TNFR-Cys repeat regions. Except for interacting with HCV core protein, LTBR can not only associate with itself, but also can associate with TRAF3, TRAF4 and TRAF5. As the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT, LTBR promotes apoptosis via TRAF3 and TRAF5. Furthermore, LTBR may play a role in the development of lymphoid organs.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Tumor necrosis factor receptor superfamily member 3

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    2 詳細

  • 最新の開発ステージ:

    Phase 1 Clinical

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