Human Mesothelin / MSLN (391-598) Protein, Fc Tag (MALS verified)

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製品番号/仕様
価格
数量
MSN-H5267-100ug
$455.00
MSN-H5267-1mg (500ug X 2)
$2470.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    MSLN, Mesothelin, MPF

  • Source

    Human Mesothelin (391-598), Fc Tag (MSN-H5267) is expressed from human 293 cells (HEK293). It contains AA Ser 391 - Ser 598 (Accession # AAH09272.1).

    Predicted N-terminus: Pro

    Request for sequence
  • Molecular Characterization

    Mesothelin Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 49.6 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.2 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    Mesothelin SDS-PAGE

    Human Mesothelin (391-598), Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    Mesothelin SEC-MALS

    The purity of Human Mesothelin (391-598), Fc Tag (Cat. No. MSN-H5267) is more than 90% and the molecular weight of this protein is around 95-120 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     Mesothelin ELISA

    Immobilized Human Mesothelin (391-598), Fc Tag (Cat. No. MSN-H5267) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human MSLN Antibody, Human IgG1 with a linear range of 0.156-5 μg/mL (QC tested).

    Protocol

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バックグランド

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Mesothelin

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    55 詳細

  • 最新の開発ステージ:

    Phase 2 Clinical

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