Mouse Nectin-4 Protein, Fc Tag (MALS verified)

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NE4-M5257-100ug
$360.00
In Stock - Delivery in 1-2 business days
NE4-M5257-1mg (500ug X 2)
$2,615.00
In Stock - Delivery in 1-2 business days
NE4-M5257
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Synonyms

NECTIN4, LNIR, PRR4, PVRL4

Source

Mouse Nectin-4, Fc Tag (NE4-M5257) is expressed from human 293 cells (HEK293). It contains AA Gly 31 - Ser 347 (Accession # Q8R007-1).

Predicted N-terminus: Gly 31

Molecular Characterization

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 60.8 kDa. The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 0.1 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.

バックグランド

Nectin-4 (Nectin Cell Adhesion Molecule 4) is a member of the nectin family of immunoglobulin-like cell adhesion molecules. It is highly expressed during embryonic development but shows limited expression in most normal adult tissues. Nectin-4 is overexpressed in a variety of solid tumors, including bladder, breast, lung, pancreatic and ovarian cancers, and has been associated with tumor growth, invasion and metastasis. Studies have shown that Nectin-4 contributes to tumor progression through multiple signaling pathways, including PI3K/Akt signaling. Due to its restricted expression in normal tissues and elevated expression in malignant tumors, Nectin-4 has emerged as an attractive therapeutic target for cancer diagnosis and treatment.