Human NKp44 / NCR2 / CD336 Protein, Llama IgG2b Fc Tag, low endotoxin

Cat. No. / Size
Price
Availability
Qty
NC2-H5258-100ug
$390.00
In Stock - Delivery in 1-2 business days
NC2-H5258-1mg (250ug X 4)
$2,575.00
In Stock - Delivery in 2 weeks
NC2-H5258
Sub-Total :
$ 0
Customize Product Request Quote
Contact Us
Contact Us
Sub-Total:
$ 0
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

Natural cytotoxicity triggering receptor 2, NKp44, NCR2, CD336, LY95

Source

Human NKp44, Llama IgG2b Fc Tag (NC2-H5258) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Ala 192 (Accession # O95944-1).

Predicted N-terminus: Gln 22

Molecular Characterization

This protein carries a llama IgG2b Fc tag at the C-terminus.

The protein has a calculated MW of 46.5 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 0.01 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.

Background

NKp44, a member of Natural Cytotoxicity Receptors (NCRs), is an activating receptor playing a crucial role in most functions exerted by activated NK cells and also by other NKp44+ immune cells. Membrane-associated PC is a ligand for the NKp44 (NCR2) innate immune receptorMembrane-associated PC is a ligand for the NKp44 (NCR2) innate immune receptor. NKp44 / NCR2 / CD336 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.