Human OSMR beta Protein, Fc Tag, low endotoxin (MALS verified)

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Cat. No. / Size
Price
Qty
OSR-H5253-100ug
$395.00
OSR-H5253-1mg (500ug X 2)
$2500.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    Oncostatin-M-specific receptor subunit beta, Interleukin-31 receptor subunit beta, IL-31 receptor subunit beta, IL-31R subunit beta, IL-31R-beta, IL-31RB, OSMR, OSMRB

  • Source

    Human OSMR Protein, Fc Tag (OSR-H5253) is expressed from human 293 cells (HEK293). It contains AA Glu 28 - Met 740 (Accession # Q99650-1).

    Predicted N-terminus: Glu 28

    Request for sequence
  • Molecular Characterization

    OSMR Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 107.6 kDa. The protein migrates as 130-170 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    OSMR SDS-PAGE

    Human OSMR Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    OSMR SEC-MALS

    The purity of Human OSMR Protein, Fc Tag (Cat. No. OSR-H5253) is more than 95% and the molecular weight of this protein is around 260-310 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     OSMR ELISA

    Immobilized Human OSMR Protein, Fc Tag (Cat. No. OSR-H5253) at 1 μg/mL (100 μL/well) can bind Vixarelimab with a linear range of 0.1-6 ng/mL (QC tested).

    Protocol

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Background

Oncostatin-M-specific receptor subunit beta (OSMRβ), also known as Interleukin-31 receptor subunit beta (IL-31RB), is the beta subunit of the type II OSM receptor, which is a heterodimer of gp130 and OSMRβ. OSMRβ associates with the low-affinity OSM·gp130 complex to form a high-affinity heterodimeric receptor that is capable of transducing OSM-specific signaling events.

Recent Advances

 
Drug Development Progress
  • English Name:

    Oncostatin-M-specific receptor subunit beta

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    1 Details

  • Highest Development Stage:

    Phase 2 Clinical

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