Cynomolgus PVRIG Protein, His Tag (MALS verified)

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製品番号/仕様
価格
数量
PVG-C52H3-100ug
$360.00
PVG-C52H3-1mg
$2380.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    C7orf15, C7orf15MGC138295, CD112R, MGC104322, MGC138297, MGC2463, PVRIG, CD112 receptor

  • Source

    Cynomolgus PVRIG Protein, His Tag (PVG-C52H3) is expressed from human 293 cells (HEK293). It contains AA Thr 41 - Asp 171 (Accession # A0A2K5WVV8-1).

    Predicted N-terminus: Thr 41

    Request for sequence
  • Molecular Characterization

    PVRIG Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 15.6 kDa. The protein migrates as 20-27 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.1 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    PVRIG SDS-PAGE

    Cynomolgus PVRIG Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    PVRIG SEC-MALS

    The purity of Cynomolgus PVRIG Protein, His Tag (Cat. No. PVG-C52H3) is more than 95% and the molecular weight of this protein is around 18-28 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     PVRIG ELISA

    Immobilized Cynomolgus PVRIG Protein, His Tag (Cat. No. PVG-C52H3) at 5 μg/mL (100 μL/well) can bind Biotinylated Human Nectin-2, Mouse IgG2a Fc,Avitag (Cat. No. CD2-H82A3) with a linear range of 0.3-5 ng/mL (QC tested).

    Protocol
  •  PVRIG ELISA

    Immobilized Human Nectin-2, Fc Tag (Cat. No. PV2-H5253) at 5 μg/mL (100 μL/well) can bind Cynomolgus PVRIG Protein, His Tag (Cat. No. PVG-C52H3) with a linear range of 0.02-0.625 μg/mL (Routinely tested).

    Protocol

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バックグランド

Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. Notably, the intracellular domain of phatases. The extracellular domain sequence of human and mouse CD112R have 65.3% similarity. CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Transmembrane protein PVRIG

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    7 詳細

  • 最新の開発ステージ:

    Phase 2 Clinical

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