Recombinant Microbial Transglutaminase, mTGase (High Specific Activity)

Microbial Transglutaminase (mTGase) is an enzyme that catalyzes acyl transfer reactions between the γ-carboxamide groups of glutamine residues in proteins or peptides and primary amines, forming stable covalent bonds. The enzyme can also catalyze hydrolytic deamidation reactions under suitable conditions. It is widely used in protein cross-linking, protein modification, and antibody-drug conjugate (ADC) development.

Site-specific conjugation for antibody-drug conjugate (ADC) development
Antibody and protein labeling with functional molecules
Protein cross-linking and modification
Hydrolytic deamidation of glutamine residues in proteins and peptides

One unit is defined as the amount of enzyme, which causes the formation of 1.0 μmole of L-Glutamic-γ-monohydroxamic acidper minute by catalysing the reaction between CBZ-Gln-Gly and hydroxylamine at pH 6.0 at 37°C.

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

＞60 U/mg

Less than 1.0 EU per μg by the LAL method / rFC method.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

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This product is shipped at ambient temperature.

• This product is shipped at ambient temperature.
• This product is stable after storage at:
• In lyophilized state for 2 year (-20℃); After reconstitution under sterile conditions for 12 months (-70℃).