Human TGFR-1 / ALK-5 / TGF-beta receptor type-1 Protein, Llama IgG2b Fc Tag (SPR verified)

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製品番号/仕様
価格
数量
TG1-H5259-100ug
$390.00
TG1-H5259-1mg (500ug X 2)
$2575.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    TGFR-1, ALK-5, TGF-beta receptor type-1, Activin receptor-like kinase 5

  • Source

    Human TGF-beta RI Protein, Llama IgG2b Fc Tag (TG1-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 34 - Leu 126 (Accession # P36897-1).

    Predicted N-terminus: Leu 34

    Request for sequence
  • Molecular Characterization

    TGF-beta RI Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a llama IgG2b Fc tag at the C-terminus.

    The protein has a calculated MW of 38.0 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    TGF-beta RI SDS-PAGE

    Human TGF-beta RI Protein, Llama IgG2b Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • Bioactivity-SPR

     TGF-beta RI SPR

    Biotinylated Human TGF-Beta 1, Avitag (Cat. No. TG1-H8217) immobilized on SA Chip can bind Human TGF-beta RI, Llama IgG2b Fc Tag (Cat. No. TG1-H5259) with an affinity constant of 83.7 nM as determined in a SPR assay (Biacore 8K) (QC tested).

    Protocol

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バックグランド

TGF type I receptor also called the activin receptor-like kinase 5 (ALK5) and involved in TGF signaling. TGFβ signaling is mediated by the interaction of TGFβ ligands (TGFβ 1, 2 or 3) with cell surface receptors, the TGF type I, type II and type III receptors. Signaling is initiated by binding of TGF to the TGF type II receptor forming a ligand-receptor complex which interacts with the TGF type I receptor.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Transforming growth factor beta receptor 1

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    7 詳細

  • 最新の開発ステージ:

    Phase 3 Clinical

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