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TLR8,CD288,Toll-like receptor 8
Human TLR8, Fc Tag (TL8-H5253) is expressed from human 293 cells (HEK293). It contains AA Glu 27 - Thr 827 (Accession # Q9NR97-1).
Predicted N-terminus: Glu 27
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 117.9 kDa.
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Toll-like receptors (TLRs) sense pathogen-associated molecular patterns originating from invading microorganisms and initiate innate immune responses. Toll-like receptors 8 and 7 (TLR8 and TLR7) are endosomal immune receptors and take a key role in innate and adaptive immunity. As a transmembrane receptor, TLR8 could recognize single-stranded RNA. Activation of TLR8 and TLR7 lead to immune cell stimulation and inflammatory cytokine production, which is normally a protective host response.