Human TNFR2 / CD120b / TNFRSF1B Protein, Fc Tag (MALS verified)

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Cat. No. / Size
Price
Qty
TN2-H5253-50ug
$270.00
TN2-H5253-1mg (500ug X 2)
$1950.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    TNFRSF1B, CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR

  • Source

    Human TNFR2 / CD120b / TNFRSF1B Protein, Fc Tag (TN2-H5253) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Asp 257 (Accession # P20333-1).

    Predicted N-terminus: Leu 23

    Request for sequence
  • Molecular Characterization

    TNFR2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 51.6 kDa. The protein migrates as 66-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    TNFR2 SDS-PAGE

    Human TNFR2 / CD120b / TNFRSF1B Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • SEC-MALS

    TNFR2 SEC-MALS

    The purity of Human TNFR2 / CD120b / TNFRSF1B Protein, Fc Tag (Cat. No. TN2-H5253) is more than 90% and the molecular weight of this protein is around 120-140 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     TNFR2 ELISA

    Immobilized Human TNFR2 / CD120b / TNFRSF1B Protein, Fc Tag (Cat. No. TN2-H5253) at 5 μg/mL (100 μL/well) can bind Biotinylated Human TNF-alpha, His,Avitag (Cat. No. TNA-H82E3) with a linear range of 0.1-6 ng/mL (QC tested).

    Protocol

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Background

TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha. It has a much lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most of the metabolic effects of TNF-alpha.

Recent Advances

 
Drug Development Progress
  • English Name:

    Tumor necrosis factor receptor superfamily member 1B

  • Category:

  • Approved Drugs:

    1 Details

  • Drugs in Clinical Trials:

    8 Details

  • Highest Development Stage:

    Approved

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