Cynomolgus / Rhesus macaque TPBG / 5T4 Protein, His Tag

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製品番号/仕様
価格
数量
TPG-C52H3-100ug
$360.00
TPG-C52H3-1mg
$2615.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    TPBG, 5T4, M6P1, 5T4AG, WAIF1, 5T4 oncofetal antigen, Trophoblast glycoprotein, 5T4 oncofetal trophoblast glycoprotein

  • Source

    Cynomolgus / Rhesus macaque TPBG, His Tag (TPG-C52H3) is expressed from human 293 cells (HEK293). It contains AA Thr 35 - Ser 355 (Accession # Q4R8Y9-1). In the region Thr 35 - Ser 355, the amino acid sequences of Cynomolgus and Rhesus macaque TPBG are identical.

    Predicted N-terminus: Thr 35

    Request for sequence
  • Molecular Characterization

    TPBG Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 36.7 kDa. The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    TPBG SDS-PAGE

    Cynomolgus / Rhesus macaque TPBG, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • Bioactivity-ELISA

     TPBG ELISA

    Immobilized Cynomolgus / Rhesus macaque TPBG, His Tag (Cat. No. TPG-C52H3) at 1 μg/mL (100 μL/well) can bind Anti-TPBG Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

    Protocol

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バックグランド

Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues.This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Trophoblast glycoprotein

  • カテゴリ:

  • 市販の医薬品数:

    0 詳細

  • 治験医薬品数:

    16 詳細

  • 最新の開発ステージ:

    Phase 2 Clinical

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