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Human ULBP4 Protein, His Tag (MALS verified)

COADS MS
DS

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UL4-H52H3-100ug
$360.00
In Stock - Delivery in 1-2 business days
UL4-H52H3-1mg (500ug X 2)
$2615.00
In Stock - Delivery in 2 weeks
総アイテム数 製品金額$ 0
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製品詳細

  • Synonyms

    LETAL, N2DL-4, NKG2DL4, RAET1E2, RL-4, ULBP4, bA350J20.7

  • Source

    Human ULBP4 Protein, His Tag (UL4-H52H3) is expressed from human 293 cells (HEK293). It contains AA His 31 - Asp 225 (Accession # Q8TD07).

    Predicted N-terminus: His 31

    Request for sequence

  • Molecular Characterization

    ULBP4 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 24.3 kDa. The protein migrates as 33-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    ULBP4 SDS-PAGE

    Human ULBP4 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    ULBP4 SEC-MALS

    The purity of Human ULBP4 Protein, His Tag (Cat. No. UL4-H52H3) is more than 90% and the molecular weight of this protein is around 30-45 kDa verified by SEC-MALS.

    Report

  • Bioactivity-ELISA

    ULBP4 ELISA

    Immobilized Human NKG2D Protein, Fc Tag (Cat. No. NKD-H5265) at 5 μg/mL (100 μL/well) can bind Human ULBP4 Protein, His Tag (Cat. No. UL4-H52H3) with a linear range of 1-78 ng/mL (QC tested).

    Protocol

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  • product

    Can lyophilized proteins remain stable during room-temperature shipping or temporary room-temperature exposure?

    In general, lyophilized proteins remain stable during room-temperature shipping or temporary exposure to room-temperature conditions.


    Many ACROBiosystems recombinant proteins are supplied in lyophilized (freeze-dried) form. The lyophilization process effectively removes moisture from the product, helping reduce degradation-related reactions and improve protein stability during transportation and storage.


    To evaluate the stability of lyophilized proteins under normal temperature conditions, ACROBiosystems conducted a stability study on 11 representative lyophilized protein products at 37°C. The study demonstrated that these proteins maintained good quality stability after storage at 37°C for approximately 20 days. Based on these validation results, temporary room-temperature exposure during shipping or handling is generally not expected to have a significant impact on product quality or downstream application performance.


    To ensure optimal long-term stability, products should be stored according to the storage conditions specified in the product Certificate of Analysis (COA) upon receipt.


    Supporting Document


バックグランド

ULBP4 (UL16-binding protein 4), also known as RAET1E (retinoic acid early transcript 1E), NKG2DL4 (NKG2D ligand 4) and LETAL (lymphocyte effector cell toxicity activating ligand), is a member of the ULBP/RAET1 family. This and ULBP-5/RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses.

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