Mouse VCAM-1 / CD106 Protein, His Tag (MALS verified)

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製品番号/仕様
価格
数量
VC1-M52H3-100ug
$260.00
VC1-M52H3-1mg
$1700.00
ETA of in-stock products:2 business days
総アイテム数 製品金額$ 0

製品詳細

  • Synonyms

    VCAM1, CD106, INCAM-100, V-CAM 1, VCAM-1

  • Source

    Mouse VCAM-1 Protein, His Tag (VC1-M52H3) is expressed from human 293 cells (HEK293). It contains AA Phe 25 - Glu 698 (Accession # P29533-1).

    Predicted N-terminus: Phe 25

    Request for sequence
  • Molecular Characterization

    VCAM-1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 76.3 kDa. The protein migrates as 85-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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データ表示

  • SDS-PAGE

    VCAM-1 SDS-PAGE

    Mouse VCAM-1 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    VCAM-1 SEC-MALS

    The purity of Mouse VCAM-1 Protein, His Tag (Cat. No. VC1-M52H3) is more than 90% and the molecular weight of this protein is around 80-115 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     VCAM-1 ELISA

    Immobilized Mouse VCAM-1 Protein, His Tag (Cat. No. VC1-M52H3) at 5 μg/mL (100 μL/well) can bind Biotinylated Human ITGA4&ITGB1 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT1-H82W1) with a linear range of 0.005-0.156 μg/mL (QC tested).

    Protocol

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バックグランド

Vascular cell adhesion protein 1 (VCAM1) is also known as CD106, INCAM-100 and L1CAM, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. VCAM1 / CD106 contains 7 Ig-like C2-type (immunoglobulin-like) domains. CD106 / VCAM-1 is expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. L1CAM / VCAM-1 is Important in cell-cell recognition and appears to function in leukocyte-endothelial cell adhesion. CD106 / VCAM1 interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1 / VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. INCAM-100 / VCAM1 binds to ECMV-D capsid proteins and acts as a receptor for this virus.

最新の進展

 
医薬品開発の進捗
  • 英語名:

    Vascular cell adhesion molecule 1

  • カテゴリ:

  • 市販の医薬品数:

    2 詳細

  • 治験医薬品数:

    1 詳細

  • 最新の開発ステージ:

    Approved

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