pH Sensitive Anti-Human IgG Labeling Reagent

Application

In in vivo CAR research, the endocytic capacity of tLNP is a key factor for evaluation of the delivery efficiency. Our pH-sensitive Anti-Human IgG Labeling Reagent (Cat. IGG-ZFS307) specifically binds to the Fc region of human IgG antibodies, and the pH-sensitive dye can significantly enhance the fluorescence signal in an acidic environment. This enables FACS analysis to evaluate the endocytic efficiency of IgG-format antibody-conjugated LNPs.

Features

1. High signal-to-noise ratio – Strong fluorescence signal with minimal background
2. Fc-specific targeting – Preserves antibody–antigen interaction
3. Application validated – FACS-ready for tLNP uptake studies

Specificity

Specifically binds to the Fc region of human IgG without recognizing Fab fragments or mouse IgG isotypes.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 24 months in lyophilized state;
2. -20°C to -70°C for 12 months after reconstitution.

ACRO Quality Management System

1. QMS(ISO, GMP)
2. Quality Advantages
3. Quality Control Process