ActiveMax® Beads
ActiveMax® is our brand of biocompatible magnetic beads pre-conjugated with our own highly active recombinant proteins designed for cell activation, culture, and other application scenarios. Our ActiveMax® products are manufactured with strict quality requirements for cell manufacturing use including animal origin-free, sterile, mycoplasma free, and ultralow endotoxins. This ensures that our products meet all of your needs for immune cell therapy related research to preclinical process development, before seamlessly transitioning to GMP-grade.
In addition, we also provide sterile cell-grade streptavidin magnetic beads, which can help you quickly achieve personalized preparation of various cell-grade protein/antibody-coupled magnetic beads.
ActiveMax® Beads
- Target-specific Magnetic Beads
- Antibody-coupled Magnetic Beads
- Streptavidin-coupled Magnetic Beads
- Custom Services
Target-specific Magnetic Beads
Feature: Target-specific Activation Beads
Click here to customize more targets.
CAR Cell Activation and Expansion
The use of antigenic polymers based on magnetic bead coupled can effectively activate CAR-T cells with specificity.
CAR Cell In Vitro Analysis
After co-incubation with CAR-T cells using target-specific activation beads, in vitro analyses such as T cell activation, proliferation, and cytokine release were performed to locate product characterization and release testing.
CAR Cell Enrichment
Target-specific magnetic beads can be used to enrich low abundance CAR cells or rare CAR-T cells
Typical Data
BCMA CAR-T cells were stimulated with ActiveMax® Human BCMA μBeads (MBS-C004) for 24 h , and cell-free supernatants were harvested for evaluating IFN-γ、TNF-α、IL-4、IL-6 secretion by flow cytomtry. The results showed that BCMA CAR-T cells released significantly larger amounts of IFN-γ、TNF-α、IL-4、IL-6 into the supernatants in response to BCMA μBeads.
Antibody-coupled Magnetic Beads
Streptavidin-coupled Magnetic Beads
Feature: Sterile Streptavidin-coupled Magnetic Beads
Typical Data
ActiveMax Streptavidin coupled μbeads, premium grade coupled with protein. 40ug of the biotinylated human BCMA protein (Cat. No. BCA-H82E4) was added to 1mg of ActiveMax Streptavidin coupled μbeads, premium grade (for cells) (Cat. No. MBS-C009), mix well and incubate for 60 mins at room temperature. And then the coupled μbeads were fluorescently stained using PE labeled anti-human BCMA antibody and analyzed by flow cytometry.
ActiveMax Streptavidin coupled μbeads, premium grade coupled with human BCMA protein. The biotinylated human BCMA protein (Cat. No. BCA-H82E4) in serial dose was added to 1mg of ActiveMax Streptavidin coupled μbeads, premium grade (for cells) (Cat. No. MBS-C009), mix well and incubate for 60 mins at room temperature. And then the unbound protein in supernatant measured by Micro BCA Protein Assay Kit was subtracted to calculate the BCMA protein coupled amount on the μbeads (loaded capacity).
ActiveMax Streptavidin coupled μbeads, premium grade coupled with antibody. 50ug of the biotinylated anit-FMC63 Antibody (Cat. No. FM3-BY54) was added to 1mg of ActiveMax Streptavidin coupled μbeads, premium grade (for cells) (Cat. No. MBS-C009), mix well and incubate for 60 mins at room temperature. And then the coupled μbeads were fluorescently stained using PE labeled anti-mouse Fc antibody and analyzed by flow cytometry.
ActiveMax Streptavidin coupled μbeads, premium grade coupled with antibody. The anit-FMC63 Antibody (Cat. No. FM3-BY54) in serial dose was added to 1mg of ActiveMax Streptavidin coupled μbeads, premium grade (for cells) (Cat. No. MBS-C009), mix well and incubate for 60 mins at room temperature. And then the unbound protein in supernatant measured by Micro BCA Protein Assay Kit was subtracted to calculate the antibody coupled amount on the μbeads (loaded capacity).
Custom Services
Custom Services
We are dedicated to delivering highly specialized solutions for cell therapy and a range of other applications. Utilizing the advanced capabilities of the ActiveMax platform, we provide bespoke coupled magnetic bead products tailored to your precise research requirements, thereby expediting your drug development journey.
Different conjugation methods, different bead sizes, Tailor the beads to your specific research needs.
Personalization
Thousands of target proteins are ready-made and provided for free in coupled Magnetic Beads.
Comprehensive Proteins
Maintain high standards with sterile, animal origin-free, and ultra-low endotoxin products.
Stringent Quality Control
A robust GMP quality management system ensures a seamless transition from early development to clinical production.
Seamless Transition to GMP-grade
- Target-specific Magnetic Beads
- Antibody-coupled Magnetic Beads
- Streptavidin-coupled Magnetic Beads
- Custom Services
Target-specific Magnetic Beads
Feature: Target-specific Activation Beads
Click here to customize more targets.
CAR Cell Activation and Expansion
The use of antigenic polymers based on magnetic bead coupled can effectively activate CAR-T cells with specificity.
CAR Cell In Vitro Analysis
After co-incubation with CAR-T cells using target-specific activation beads, in vitro analyses such as T cell activation, proliferation, and cytokine release were performed to locate product characterization and release testing.
CAR Cell Enrichment
Target-specific magnetic beads can be used to enrich low abundance CAR cells or rare CAR-T cells
Typical Data
BCMA CAR-T cells were stimulated with ActiveMax® Human BCMA μBeads (MBS-C004) for 24 h , and cell-free supernatants were harvested for evaluating IFN-γ、TNF-α、IL-4、IL-6 secretion by flow cytomtry. The results showed that BCMA CAR-T cells released significantly larger amounts of IFN-γ、TNF-α、IL-4、IL-6 into the supernatants in response to BCMA μBeads.
- Background
- ActiveMax® Beads
Online Message
お問い合わせ
グローバル：+1 800-810-0816(Toll Free)
メールアドレス
order.jp@acrobiosystems.com
アクロバイオシステムズ株式会社
〒101-0051
東京都千代田区神田神保町1-32-8